Since TRPM4 activity has been proposed to contribute to the pathophysiology of different cancers, and TRPM4 and KCTD5 expression are increased in breast cancer (in particular in the most aggressive subtype, the triple negative one), study of the TRPM4-KCTD5 protein interaction could be useful to develop drugs that modulate their activity with therapeutics purposes [111]. Here, KCTD5 is linked to breast cancer.