Furthermore, recurrent germline mutations of MLH1 V384D, in the absence of high-TMB, were found in ~ 14 % of HR+/HER2+ breast cancers in East Asian patients, suggesting that in this subset of neoplasms MLH1 haploinsufficiency is more likely to contribute to tumor predisposition factor rather than to constitute a direct oncogenic driver [57]. This evidence concerns the gene MLH1 and breast cancer.