PBX3 and gastric cancer: To sum up, the investigation manifested an unappreciated molecular mechanism of circHECTD1 on DB-sensitivity through adopting miR-137/PBX3 axis via altering cell viability, cell-cycle arrest and apoptosis in DB-induced GC cells, which might provide theoretical support for the application of circHECTD1 as a novel therapeutic strategy for GC patients.