We then performed univariate analyses and multivariate analyses on OS in the total 129 AML patients, including the expression level of PRICKLE1, age, WBC, cytogenetic risk and NPM1/FLT3-ITD/CEBPA/DNMT3A/IDH1/IDH2 mutations (mutant vs. wild-type). The gene discussed is NPM1; the disease is acute myeloid leukemia.