In the previous analysis of three publicly available gene expression profiles for GC, novel prognosis-associated four-gene signatures, such as NOGGIN, RBPMS2, CTSF, and CUEDC1, showed a moderate performance with an area under ROC curve (AUC) of 0.745 for the prediction of 5-year survival [7]. The gene discussed is RBPMS2; the disease is gastric cancer.