Although there might be a possibility of independent mechanisms between CNO‐ and DCP‐elicited itch, it was hypothesized that the itch‐inducible roles of spinal GRP+ neurons were amplified under chronic itching conditions, as the expression level of GRP was markedly increased in the SDH under chronic itching conditions, and that chemogenetic inhibition of GRP+ neurons attenuated DCP‐elicited itch in our previous report.15 The gene discussed is GRP; the disease is Pruritus.