It is also noteworthy that in ovarian, prostate and pancreatic cancer, FILIP1L expression is silenced by DNA hypermethylation; this has been linked to aggressiveness and metastatic potential, and is even considered an independent prognostic marker in ovarian cancer [47,[50], [51], [52], [53]]. The gene discussed is FILIP1L; the disease is familial pancreatic carcinoma.