Importantly, sulforaphane has been shown to attenuate a number of UVR-induced DMRs, e.g. within Notch1 and Smad6, in the mouse skin and reduce the incidence and multiplicity of skin cancer [58], in agreement with our early observations using broccoli extracts as delivery vehicles for sulforaphane [59,60]. Here, NOTCH1 is linked to skin neoplasm.