Using the same approach, Subrahmanyam et al. have found that NK cells expressing both CD69 and MIP-1β likely play a critical role in the anti-tumor response triggered by anti-PD-1, whereas CD4+ and CD8+ memory T cell subsets are potential biomarker candidates for higher response rate to anti-CTLA-4 [66]. The gene discussed is CD8A; the disease is neoplasm.