RNF43 and gastric neoplasm: RNF43 mutation is also common in stomach, corpus uteri, and other cancers, one of which is the highly recurrent RNF43 frame-shift mutation, G659Vfs (Fig. 3).The loss of RNF43 protein expression is significantly more common in colorectal and gastric tumor samples with G659Vfs than in those with WT RNF43 (39).