RNF43 mutation is also common in stomach, corpus uteri, and other cancers, one of which is the highly recurrent RNF43 frame-shift mutation, G659Vfs (Fig. 3).The loss of RNF43 protein expression is significantly more common in colorectal and gastric tumor samples with G659Vfs than in those with WT RNF43 (39). Here, RNF43 is linked to cancer.