NLRP3 and cryopyrin-associated periodic syndrome: Genetic analysis can corroborate the clinical suspicion of CAPS, but around 40% of patients might not carry a specific NLRP3 mutation at the conventional Sanger sequencing test, while the application of novel more sensitive genetic methods like next-generation sequencing can disclose somatic mosaicism, consistent with specific NLRP3 mutations occurred during embryogenesis [12].