A pyogenic autosomal-recessive disease caused by LPIN2 mutations and leading to abnormal function of lipin-2, a phosphatidate phosphatase involved in the glycerolipid biosynthesis, is Majeed syndrome: this disease is defined by early-onset recurrent multifocal osteomyelitis, neutrophilic dermatosis and congenital dyserythropoietic anemia [47]. Here, LPIN2 is linked to congenital dyserythropoietic anemia.