Another pyogenic disease characterized by pustular rashes, aseptic multifocal osteomyelitis and increased acute-phase reactants in newborns identifies the deficiency of the naturally occurring competitive inhibitor of IL-1, which is the IL-1 receptor antagonist (a disease named “DIRA”), caused by IL1RN mutations: the absent inhibition of IL-1 in children with DIRA can be fully treated with the IL-1 receptor antagonist anakinra [49]. The gene discussed is IL1A; the disease is osteomyelitis.