Various pyogenic disorders starting in childhood can also be considered inflammasome-related diseases, and—particularly—a rare autosomal-dominant pathology caused by mutations in the PSTPIP1 gene, named “pyogenic arthritis, pyoderma gangrenosum and acne (PAPA) syndrome”, is the most relevant [44]. The gene discussed is PSTPIP1; the disease is pyoderma gangrenosum.