Based on clinical features as well as on the new acquisitions about SJIA pathogenesis showing IL-1 dysregulation, it is justified that this disorder being included in the group of non-hereditary AIDs, and this hypothesis is also confirmed by the paramount response to anti-IL-1 agents seen in SJIA, though further data are needed to explain whether this is due to intrinsic abnormalities of caspase-1 pathway [68]. The gene discussed is CASP1; the disease is systemic-onset juvenile idiopathic arthritis.