Although the role of POU6F2-AS1 intumors still remains unclear, POU6F2-AS2 (POU6F2-antisense 2; thehomology of POU6F2-AS1) has been reported to be associated with Ybx1 protein andparticipates in the chromatin localization of Ybx1 to specially regulate theprognosis of esophageal squamous cell carcinoma (ESCC) (Liu J et al., 2016). The gene discussed is YBX1; the disease is esophageal squamous cell carcinoma.