Based on allometric scaling, a low Δ9-THCA dose (2 mg/kg) was administered to approximate low doses administered to childhood epilepsy patients.8–10 The highest dose tested (100 mg/kg) matched the dose of CBD that has been shown to be anticonvulsant against hyperthermia-induced seizures in Scn1a+/− mice.17,24 No effect was observed on the temperature threshold for thermally induced seizures at any dose (Fig. 1A). The gene discussed is SCN1A; the disease is epilepsy.