INS and obesity due to melanocortin 4 receptor deficiency: However, improvements in cholesterol were observed in children with obesity aged 7−17 years with a BMI SDS reduction of <0.1 unit,34 and improvement in insulin and cholesterol was observed in 5- to 19-year-olds with obesity, following a BMI SDS reduction of 0.15 (SD = 0.5) units.35 These findings highlight the potentially beneficial clinical effects of the OneLife Suffolk pragmatic intervention and its appropriateness among children of a wide range of ages, socioeconomic background and initial weight.