The mechanism behind lower NT‐proBNP with increasing HbA1c is unclear, but may be related to adipocyte overexpression of cytokines (the leptin‐neprilysin‐aldosterone axis),33 insulin resistance,34 or simply impaired neurohormonal hemostasis in obesity.35 The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.