Human‐induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) from a DCM patient carrying a PLN p. Arg14del mutation revealed a significantly higher spontaneous beating frequency, irregular Ca2+ transients, and lower force development than respective isogenic controls (Karakikes et al,2015; Stillitano et al,2016). This evidence concerns the gene PLN and familial dilated cardiomyopathy.