In a separate model adjusted for the BIOSTAT‐CHF risk score, NT‐proBNP, CA‐125, FGF‐23, bio‐adrenomedullin and interleukin 6, NLR remained significantly associated with both the primary outcome (HR 1.13; 95% CI 1.04–1.20, P = 0.002) and mortality alone (HR 1.14; 95% CI 1.07–1.23, P < 0.001) (Table S3). This evidence concerns the gene NPPB and congestive heart failure.