Change in expression of cullin 2, cyclin dependent kinase 2, minichromosome maintenance complex components (MCM3-5 and MCM7) and phosphoribosyl pyrophosphate amidotransferase, proteins associated in other cell types with cell cycle control, was common to both COVID-19 and non-COVID-19 ARDS, whilst proteins important for mitochondrial translational termination and cell surface receptor signalling pathways were enriched in non-COVID-19 ARDS samples (Figure 4B). This evidence concerns the gene CUL2 and COVID-19.