In both COVID-19 and non-COVID-19 ARDS, whilst we observed an equivalent abundance of primary (CD63, CD68 and Presenilin-1), secondary (Ras related proteins 1A-B and 2A-C), secondary and tertiary (secretory carrier membrane protein 1–4, vesicle associated membrane protein 2) and specifically tertiary (solute carrier 11A1) granule membrane proteins (data are available via ProteomeXchange with identifier PXD023834), there is a relative reduction in the abundance of the granule cargo proteins within these circulating cells (Figure 6B). Here, PSEN1 is linked to COVID-19.