Therefore, 9 genes were specifically expressed in HPV-negative cervical cancer, including PRAME, HMGA2, SBK1, MEX3A, TM7SF2, SLC19A1, ETV4, PYCR1, and TTYH3, compared to HPV-positive cervical cancer and normal cervical tissues. The gene discussed is SBK1; the disease is cervical carcinoma.