A subsequent multiplatform integrative analysis revealed that 11 genes, PRAME, HMGA2, SBK1, ETV4, MEX3A, PLS1, TM7SF2, PYCR1, SLC19A1, TTYH3, and NIPSNAP1, displayed upregulated mRNA levels, and 8 specific genes, PRAME, HMGA2, ETV4, MEX3A, TM7SF2, SLC19A1, TTYH3, and NIPSNAP1, displayed upregulated protein levels in HPV-negative cervical cancer cells compared to HPV-positive cervical cancer cells and normal cervical squamous cells. The gene discussed is PRAME; the disease is cervical cancer.