Higher expression of PRAME, HMGA2, SBK1, MEX3A, TM7SF2, and SLC19A1 was detected in HPV-negative and HPV-positive cervical cancer tissues than in normal cervical tissues, and these 6 proteins were also expressed at higher levels in HPV-negative cervical cancer tissues than HPV-positive cervical cancer tissues (Figure 5). The gene discussed is PRAME; the disease is cervical cancer.