Urinary CD163 levels were significantly higher in patients with systemic vasculitis [median 68.20, IQ (38.25~158.78) (pg/ml)] compared to essential hypertension [median 43.86, IQ (23.30-60.71) (pg/ml)] (p = 0.003) and the healthy volunteers [median 30.76, IQ (9.30-54.16) (pg/ml)] (p < 0.001). This evidence concerns the gene CD163 and necrotizing vasculitis.