CRP and osteoarthritis: For instance, Bartlett et al. in their 2018 study of the effect of 10 weeks of intense intermittent aerobic exercise on elderly patients with osteoarthritis showed that regular exercise, despite its resultant weight loss and reduction of fat percentage and an improvement of the innate immune cell function and the cardiorespiratory system, had no significant effect on the markers of IL-1β, IL-10, and CRP [20].