The results revealed apM1 +45 TT carriers with TyG index greater than 9.0 (OR = 22.78, 95% CI 9.56-54.30), and apM1 +45 GG/GT carriers with TyG index greater than 9.0 (OR = 19.20, 95% CI 7.96-46.31) had significantly higher risks of MetS than apM1 +45 GG/GT carriers with TyG index less than 9.0. The gene discussed is ADIPOQ; the disease is metabolic syndrome.