The number of osteoclasts/10 HPF was correlated positively and significantly with Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) in group III (OVX-control group) (r = 0.887; P < 0.05) (Figure 3(a)) and group IV (OVX-irisin-treated group) (r = 0.848; P < 0.05) (Figure 3(b)). This evidence concerns the gene FNDC5 and Insulin resistance.