IL4 and myeloid sarcoma: Neutralizing RGMa antibody can reduce the severity of experimental autoimmune encephalomyelitis (EAE) in the MS animal model; secondly, it can inhibit peripheral blood T cell proliferation, block the production of inflammatory cytokines such as IL-2, IFN-γ, IL-17, and IL-4, and significantly reduce the level of CNS inflammatory cytokines in MS patients [5, 37].