All of it together with the fact that ADAMTS12 is one of the genes up-regulated in OA with high levels in cartilage, synovial fluid and serum of arthritic patients supports the idea of ADAMTS12 to be considered as a bona fide gene for the development of anti-RA therapies (Kevorkian et al., 2004; Liu et al., 2006b; Nah et al., 2012). This evidence concerns the gene ADAMTS12 and rheumatoid arthritis.