Finally, as TMPRSS2 expression is regulated by the androgen receptor, it has been hypothesized that its crucial role in the viral infection might help explain why males have more frequently severe complications and a worse clinical outcome than females and if androgen deprivation therapy (ADT) can have a protective effect against SARS-CoV-2 infection (Montopoli et al., 2020). Here, TMPRSS2 is linked to viral infectious disease.