CALD1 and neoplasm: Those results implied the potential regulation mechanisms of CALD1 in CRC prognosis and TAM recruitments as well as polarizations, and as both intrinsic tumor features and extrinsic tumor microenvironment engage in tumor progression and macrophage polarization (Chen et al., 2019), we subsequently calculated the stromal and immune scores as well as the angiogenesis and TGF-β signaling gene sets enrichment scores of each stage III/IV pMMR CRC sample via the ESTIMATE and ssGSEA algorithms.