L-CaD is widely distributed in non-muscle cells (Sobue and Sellers, 1991; Dabrowska et al., 2004), and studies have shown that l-CaD promoted malignancy in several cancers (Kim et al., 2012; Chang et al., 2013; Lee et al., 2015; Lian et al., 2020). This evidence concerns the gene CAD and cancer.