Given the previous literature on the crosstalk between angiogenesis and TGF-β in macrophage recruitments and M2 polarizations (Allavena et al., 2008; Erreni et al., 2011; Najafi et al., 2019; Rahma and Hodi, 2019), we investigated if CALD1 correlated with the enrichments for the two gene sets in stage III/IV pMMR CRC samples. The gene discussed is CALD1; the disease is colorectal carcinoma.