As microtubule assembly underpins the structural integrity of cells and facilitate cell cycle progression (Hall, 2009; Chen and Xie, 2018), downregulation of TUBB by MS13 may inhibit cell migration, disrupt cell integrity, and subsequently lead to cell cycle arrest and apoptosis in glioblastoma and neuroblastoma cells. The gene discussed is TUBB; the disease is glioblastoma.