CLN6 and CLN8 proteins, deficient in CLN6 (also known as Kufs disease) and CLN8 disorders, respectively, form a complex (termed EGRESS: ER-to-Golgi relaying of enzymes of the lysosomal system), which recruits lysosomal enzymes in the ER to facilitate their transfer to Golgi via COPII vesicles (Bajaj et al., 2020). The gene discussed is CLN8; the disease is adult neuronal ceroid lipofuscinosis.