PARP inhibition increased DNA damage, and reduced cell viability and proliferation when combined with irradiation in pediatric high-grade glioma, ependymoma, and diffuse intrinsic pontine glioma (DIPG) cell lines in vitro (Van Vuurden et al., 2011; Chornenkyy et al., 2015). Here, PARP1 is linked to diffuse intrinsic pontine glioma.