This clarifies the stimulation of the coagulation cascade and the resultant hypercoagulable condition because procoagulant levels of factor VIII and plasminogen activator inhibitor-1 (PAI-1) have been increased, while anticoagulant levels of protein C are diminished in the late stage of NAFLD patients (34). This evidence concerns the gene SERPINE1 and metabolic dysfunction-associated steatotic liver disease.