EDN1 and fetal growth restriction: The maternal nutrient restriction increases the acetylation of histone H3K9, H3K18, and H4 and hypoxia-inducible factor-1α (HIF-1α) binding levels at the gene promoter of ET1 in pulmonary vascular ECs (PVEC) of intrauterine growth retardation (IUGR) newborn rats and continues up to 6 weeks after birth.