ZEB1 and osteoporosis: Osteoporosis-associated downregulation of zinc-finger transcription factor ZEB1 in ECs reduces CBP/p300 mediated acetylation of H3K4, H3K14, and H3K18 within the promoters of Dll4 and Notch1, thereby epigenetically suppressing Notch signaling, a critical pathway that controls bone angiogenesis and osteogenesis (Fu et al., 2020).