12 out of 15 belong to the regulation of interleukin-1, i.e., interleukin-1 production, interleukin-1 secretion, interleukin-1 beta production, interleukin-1 beta secretion, positive regulation of interleukin-1 beta secretion, regulation of interleukin-1 beta production, etc. Interleukin-1 is a family of cytokines related to liver diseases (Tsutsui et al., 2015; Barbier et al., 2019). The gene discussed is IL1B; the disease is liver disorder.