Interestingly, macrophage-derived WNT1 promotes epithelial-mesenchymal transition (EMT) in support of vascular invasion and metastasis in breast cancer (Linde et al., 2018), suggesting a WNT1-FZD2 circuit might be linked to inflammatory cell-mediated paracrine signaling in PDAC. Here, WNT1 is linked to breast carcinoma.