IRF2BP2 is necessary to mediate the anti-inflammatory and protective effects of IFN-β cytokines on stroke injury (Cruz et al., 2017), and IRF2BP2-deficient microglia block the anxiolytic effect of enhanced postnatal care (EPC) by reducing inflammatory cytokine expression in the hypothalamus (Hari et al., 2017). This evidence concerns the gene IRF2BP2 and Stroke.