In the last few years, several reports have addressed the role of PHF19 in different types of cancers, including melanoma (Ghislin et al., 2012), prostate (Jain et al., 2020), glioblastoma (Deng et al., 2018), and also hematopoietic malignancies of the lymphoid branch, such as multiple myeloma (Ren et al., 2019; Mason et al., 2020), as well as its specific role in preventing T cell exhaustion (Ji et al., 2019). The gene discussed is PHF19; the disease is cancer.