CXCR2 and central nervous system cancer: In this study, CCL2, CCL5, CXCR4, MMP9, and CXCR2 expression was found to be high in TERTmut glioma from all samples and IDHwt subgroups with high levels of neutrophil infiltration, which indicated that N2 phenotype neutrophils were associated with TERT mutation (Bonavita et al., 2016).