AKT1 and central nervous system cancer: GO analyses showed that multiple immune-related processes were enriched in TERTmut gliomas, including cytokine-cytokine receptor interaction, chemokine signaling pathway, graft-versus-host disease, intestinal immune network for IgA production, Jak-STAT signaling pathway, antigen processing and presentation, HTLV-I infection, NF-κB signaling pathway, natural killer cell-mediated cytotoxicity, and PI3K-Akt signaling pathway (Figure 2B), which verified our hypothesis that TERT promoter status is associated with immune response in glioma.