Taken together, all these data strongly suggest that lipids and proteoglycans in the membrane could play vital roles in the pathogenesis of tauopathies by mediating multiple different processes in tau propagation, such as aggregation, recruitment to the PM, secretion across the PM from donor cells, uptake in recipient cells, and release from intracellular vesicles to initiate templated misfolding. Here, MAPT is linked to tauopathy.