APP is also reported to mediate the internalization of tau oligomer and thereby tau oligomer-induced disruption of Ca2+ signaling and Ca2+-dependent gliotransmitter release in primary astrocytes (Piacentini et al., 2017), suggesting that APP may be a critical player that regulates tau-induced toxicity and cellular dysfunctions in tauopathies. The gene discussed is MAPT; the disease is tauopathy.