Of note, an increase of membrane cholesterol in primary neurons induces AD-like phenotypes, such as vesicular trafficking defect and increases of Aβ42 secretion, Aβ-mediated toxicity, and Aβ-induced tau truncation by calpain in a NMDA receptor-dependent manner (Nicholson and Ferreira, 2009; Nicholson et al., 2011; Marquer et al., 2014). Here, MAPT is linked to Alzheimer disease.