The data revealed that silencing of β-arrestin1 inhibited the EMT process in CRC cells, while overexpression of β-arrestin1 significantly promoted the EMT process in CRC cells, which were visualized by the downregulation of E-cadherin and upregulation of Snail, N-cadherin and Vimentin in CRC cells. Here, CDH2 is linked to colorectal carcinoma.