A previous study revealed that prostaglandin E2 (PGE2)-induced transactivation of the epidermal growth factor receptor (EGFR) and downstream Akt signaling through β-arrestin1 acts as a mediator in GPCR activation of c-Src, thereby promoting CRC cell migration and metastasis (Buchanan et al., 2006). This evidence concerns the gene AKT1 and colorectal carcinoma.