GPX4 and cancer: Taking oncologic diseases as examples, several scholars have proposed potential strategies for cancer treatment, and several agents have shown the ability to trigger ferroptosis of cancer cells by acting on system xc (–), Gpx4, and endoplasmic reticulum (ER) homeostasis (Bersuker et al., 2019; Liang et al., 2019; Lelièvre et al., 2020).