Future studies will be required to determine if this phenotypic model for enlarged MROs still has the potential to acquire complete physiologic functions, involves additional pathologic changes, and reproduces a model for rare congenital enlargement of the eye, termed buphthalmos, in patients with Lrp2 mutations (Pober et al., 2009; Christ et al., 2015). Here, LRP2 is linked to congenital glaucoma.