TIMP2 and ovarian cancer: ABHD11-AS1 facilitates tri-methylation at the 27th lysine residue of the histone H3 protein (H3K27me3) on the tissue inhibitor of metalloproteinase 2 (TIMP2) promoter, as mediated by PRC2, and likewise suppresses TIMP2 expression in HO8910 cells and OVCA429 ovarian cancer cells (Figure 1B).