Although GATA4 is overexpressed in PDAC (Karafin et al., 2009), and GATA6-dependent dedifferentiation of acinar cells is known to influence KRAS-induced pancreatic cancer progressio (Hermann et al., 2014), the role of GATA4 during inflammation-related PDAC progression remains unclear. This evidence concerns the gene GATA4 and pancreatic neoplasm.