NOTCH1 and leukemia: However, considering the fact that mono T-cell repopulating ability was detected in AGM region in mice and humans (Ivanovs et al., 2011; Kobayashi et al., 2019) and that freshly isolated E10.5 AGM cells developed leukemia upon NICD overexpression, it is also plausible that HSC-independent T-cell precursors may have developed leukemia.