Quantitative PCR analysis of Notch targets from total BM cells of leukemia mice revealed upregulations of Hes1, Deltex1 (Targets of Notch signaling) and IL7Rα compared to normal BM cells (Figure 3H), in line with the reports that upregulation of IL7Ra is often observed in human T-ALL cells from patients (Zenatti et al., 2011). This evidence concerns the gene HES1 and acute lymphoblastic leukemia.