NOTCH1 and acute lymphoblastic leukemia: Importantly, Notch1 mutation was detected in neonatal blood spots (Guthrie test) of the child and infant T-ALL patients, suggesting the in-utero origin of infant and child T-ALL with Notch 1 mutation, similar to infant B-ALL (Eguchi-Ishimae et al., 2008; Mansur et al., 2015).