In addition, a combination of the RePACT approach and a CRISPR screen identified known and unknown insulin regulators in T2D and obesity trajectories, including Mau2-Nipbl cohesin loading complex, a new INS gene transcription regulator, and the NuA4/Tip60 HAT complex, a new insulin secretion regulator, with possible roles in diabetes development (Fang et al., 2019). Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.