Patient SC-β cells experienced higher levels of ER and mitochondrial stress than corrected cells, and displayed higher levels of expression for apoptosis markers, as generally observed in cases of WFS1 gene deficiency (Fonseca et al., 2005, 2010; Yamada et al., 2006) and consistent with a previous Wolfram Syndrome iPSC study (Shang et al., 2014). The gene discussed is WFS1; the disease is Wolfram syndrome.