Delivery system based on L-α-phosphatidylcholine and two SHP were developed as a multi-target treatment of AD. Insoluble SHP-2-Bn was chosen for modification of phospholipid membrane to prevent oxidation and membrane denaturation, whereas, water-soluble SHP-2-16 was chosen as an AChE inhibitor. Here, NR0B2 is linked to Alzheimer disease.