MAPT and Alzheimer disease: Curcumin provision to brain against tau protein aggregation in AD is considered the most attractive approach in AD treatment where it binds with tau protein-based amyloid and shows anti-amyloid properties in the micromolar concentration range (Yang et al., 2005; Garcia-Alloza et al., 2007; Mohorko et al., 2010; Re et al., 2010; Yanagisawa et al., 2010).