The transcription of TMPRSS2 is promoted by androgen receptors, which could explain the predominance and the severity of pathological signs in COVID-19-affected men compared with women (Guan et al., 2020; Remuzzi and Remuzzi, 2020), the higher proportion of men's hospitalization (Espinosa et al., 2020) and their higher mortality rates (Onder et al., 2020). The gene discussed is TMPRSS2; the disease is COVID-19.