As expected from the shared pathomechanism, the IDDA kaleidoscope score patterns of CTLA-4 insufficiency, LRBA, or DEF6 deficiency are quite similar, but differ markedly from those with IPEX syndrome (Figure 2, lower left) or of the CD27/CD70 deficiencies (Figure 2, lower center and right panels; please see the Figure legend for data sources). The gene discussed is CD27; the disease is immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.