However, how this contributed to the cellular response was unclear since the protein product of the spliced XBP1 was not observed and genes known to be downstream of XBP1s – such as EDEM1, ER DNA J domain-containing protein 4 (ERdj4), and protein kinase inhibitor of 58 kDa (p58IPK) – were not significantly up regulated following infection. The gene discussed is XBP1; the disease is infection.