Importantly, viral-coopting of this cellular process blocks the normal clearance of these vesicles as illustrated by data showing that, in non-infected cells, EDEM1 has a half-life of about 1 hour but upon MHV infection, is still found after several hours of infection even with virus-induced host translational shutoff, indicating that there is actually defective clearance of EDEM1 in infected cells. The gene discussed is EDEM1; the disease is infection.