Furthermore, CD8+ T cells were found to be limited to stroma underlying the dysplastic cervical epithelium and were absent from the lesional epithelium in persistent lesions, whereas lesions that were permissive to the entry of intraepithelial CD8+ T cells were predicted to regress (Trimble et al., 2010), thereby underscoring the importance of intraepithelial CTLs in controlling dysplasia. Here, CD8A is linked to dysplasia.