The three ‘E’s of cancer immunoediting could be coming into play in CIN 2/3 lesions: wherein the anti-tumor armamentarium comprising of natural killer (NK) cells, dendritic cells (DCs), and effector T cells viz. CD8+ Cytotoxic T lymphocytes (CTLs) and CD4+Th1 cells, etc. and pro-tumor forces including regulatory T cells (Tregs), Myeloid-Derived Suppressor Cells (MDSCs), the M2 polarized tumor-associated macrophages (TAMs), etc. converge and the net outcome of regression/progression of the lesions would depend on which of these two forces supersedes in the dialogue (Bui and Schreiber, 2007). The gene discussed is CD8A; the disease is cancer.