ESR1 and neoplasm: Additionally, gene expression profiling of CAFs in the presence of a SERM (Methyl-Piperidinopyrazole—MPP) and a SERD (ICI-182780) revealed tempering of genes related to cell cycle and metabolism, influencing tumor advancement and angiogenesis, thus establishing that to a certain extent ERα signaling regulated their function (Kumar et al., 2016).