A synergistic relationship has been documented in cocultures of THP1 derived macrophages which are akin to M2-TAMs and CxCa cell lines: firstly, cervical cancer cells induced macrophages to migrate towards them; macrophages on their bit assisted invasion of cancer cells; secondly, tumor cells stimulated the expression of IL-1β and IL-8 in macrophages; reciprocally, macrophages promoted the secretion of VEGF-C and VEGF-A in malignant cells. This evidence concerns the gene VEGFA and neoplasm.