IL10 and cervical squamous intraepithelial neoplasia: Briefly, downregulation of co-stimulation/adhesion molecules, rise in IL-10, and drop in TNFα—a cytokine required for the maturation of LCs in the intraepithelial microenvironment—may all be contributing to dulling of the immune response in some CIN lesions which may then continue to persist/progress (Mota et al., 1999).