ESR1 and cancer: Consequently, treatment with Selective Estrogen Receptor Modulators (SERMs) and Selective Estrogen Receptor Disruptors (SERDs) checked precancer and cancer growth, albeit in animal models (Arbeit et al., 1996; Riley et al., 2003; Chung et al., 2008; Chung and Lambert, 2009; Chung et al., 2010; Spurgeon et al., 2017).