LAP3 and polycystic kidney disease: This mature form consists of a collagenase module (containing an M9N activator domain, an M9 peptidase domain with an HEXXH zinc-binding motif and a helper domain), a polycystic kidney disease-like (PKD-like) domain and 2 collagen-binding domains (CBD1 and CBD2) (Kameyama and Akama, 1971).